Comparison of Hypoglycemic Effects of Coscinium fensestratum colebr Bark and Stem in Normal Rats

This present study was conducted to evaluate the hypoglycemic effect of aqueous extract of stem and bark of Coscinium fensestratum colebr in normal rats. Total 18 rats were selected and divided into the three groups each of 6 rats. G-I given 1% gum acacia, G-II given aqueous extract of C.F stem (500 mg/kg) and G-III treated with aqueous extract of C.F bark (500 mg/kg). Test drugs were given single dose to their respective groups. Fasting and IPGTT (30, 60 and 120 min) blood was collected and serum was separated. The collected serum was used for estimation of glucose. Aqueous extract of stem showed significant decrease in glucose levels at 30, 60 and 120 min of IPGTT compared to control and bark extract. Rats treated with aqueous extracts of bark and stem showed significant decreased glucose levels compared to control group. Aqueous extract of Coscinium fensestratum colebr stem showed significant hypoglycemic effect than bark. Further studies required to isolate the phytochemicals having hypoglycemic effect in the extract.